IoT and cloud service providers are vulnerable to both internal and external threats consequently it is not possible to fully trust them with sensitive customer data. The cloud should offer a mechanism for the user to verify if the integrity of his data is being maintained or if it has been compromised, as the user cannot physically judge the data. Cloud computing is the best solution for storing this type of data. IoT has introduced secure data sharing and access management to prevent this issue. However, centralized access control presents a number of difficulties. The goal is to develop a novel DNA Encryption-based Secure Access Control and Sharing (DESACS) technique that has been proposed in an IoT-enabled Cloud environment which enhances the privacy and security of IoT data. The privacy of IoT has been increased by encrypting the data using the DNA cryptography (DNAC) encryption technique. It offers fresh hope for breaking invincible algorithms. This is a result of DNA computing's increased speed, low storage needs, and power consumption. In contrast to traditional storage media, which require 1012 nm3/bit, DNA stores memory at a density of roughly 1 bit/nm3.